That is not to say that everyone should drink wine though, and it is important to remember that when mixed with medications, even over-the-counter drugs, the resulting damage to the liver and kidneys associated with those products is increased. The heavy consumption of wine in fact, raises the risk of some diseases that it is known to reduce the risk of. With people suffering the effects of diabetes, or gastrointestinal disorders such as ulcers wine should be avoided, and when paired with certain situations it can be dangerous to drink wine, such is the case when operating a motor vehicle. Wine may also impair a person's judgment and in some cases may cause migraine headaches, though changes in the fermentation process have lowered the risk of severe headaches.

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Two non-alcoholic chemicals known as flavanoids and reservatrol are connected with the benefits of drinking wine. Wine also includes anti-oxidants and several key vitamins that are important to a nutritional diet. These benefits are more closely associated with the consumption of red wine, whose fermentation process includes a longer duration of time with the skin of the grape intact.